онкологическое заболевание у кота

Diagnostic Veterinary Pathology Services
Ana Maria Botero-Anug, DVM. DVSc, DACVP דר« אנה מריה בוטר&# 1493;-ענוג
Yehosa Ben Hanania 81, Rehovot, 76391 יהוש&# 1506; בן חנני&# 1492; 81, רחוב&# 1493;ת, 76391
Tel/fax 08 935 4193 טל/פק& #1505; 4193 935 08
Cellular 054 799 9516 054 799 9516

Date: November 25, 2014
ID#: AR 0530/14 Z14-498
Practitioner: Dr. Lavon Owner: Tanin Tatiana
Tel: 09-882 7821, 09-8842164
Fax: 09 832 1833
E-mail: yaronlav1@walla.com; cber28@gmail.com; marlamlavon@gmail.com
Species: Feline Breed: MB MC Age: 14.8 y

 Sample submitted: Histology (601). Two tissue sections white and firm. One of them has a 1 cm diameter and the second one is 0.9 cm in diameter.
 History: Exploratory laparotomy. Very large mass in the mesentery approximately 5 x 5 cm.

 Description:
Two tissue sections with very similar histological characteristics were examined. There is diffuse infiltration with numerous round cells present in a monomorphic population. The cells have round vacuolated nucleolus, central prominent large nucleolus and moderate amounts of vacuolated cytoplasm with some degree of basophilia and well defined borders. The cells are infiltrating among six collagen bundles and areas of extensive fibrosis. Eosinophils are rare and scattered throughout.

 Diagnosis
Neoplasia, findings most compatible with sclerosing mast cell tumor

 Comments
Even though cytoplasmic granulation is poor, (which is typical of mast cell tumors in feline), the location, presence of eosinophils, cell type and evidence of thick collagen bands, are all very compatible with the described sclerosing mast cell tumor in the intestine.
For your information pasted below is the abstract of the published report.

Vet Comp Oncol. 2010 Mar;8(1):72-9. doi: 10.1111/j.1476-5829.2009.00206.x.
Feline intestinal sclerosing mast cell tumour: 50 cases (1997-2008).
Halsey CH1, Powers BE, Kamstock DA.
Author information
Abstract
This case series presents a unique and unreported variant of feline intestinal mast cell tumor recognized at the CSU Veterinary Diagnostic Laboratory. Fifty cases of feline intestinal mast cell tumors described as having a significant stromal component were reviewed. Neoplastic cells formed a trabecular pattern admixed with moderate to abundant dense stromal collagen (sclerosis). Neoplastic cells had poorly discernible intracytoplasmic granules which demonstrated metachromasia with special histochemical stains consistent with mast cell granules. Additionally, a subset of cases stained for mast cell-specific tryptase and c-kit demonstrated positive immunoreactivity. Eosinophilic infiltrates were moderate to marked in almost all cases. Lymph node and hepatic metastases were present in 66% of the cases. Treatment and clinical outcome was available in 25/50 cases. Twenty-three of these patients died or were euthanized within 2 months of initial diagnosis. This is the first case series to characterize a sclerosing variant of intestinal mast cell tumour in the cat which appears to have a high propensity for metastasis and a guarded prognosis


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Действительно ли ничего нельзя было сделать и не могла ли операция (опухоль была неоперабельна) повлиять на рост опухоли?